Dr. Alexander E. Kalyuzyhny received his B.S. and M.S. from the Department of Biochemistry & Biophysics at the Saratov State University (Russia) in 1981. He investigated the mechanisms underlying pre-implantation development of mouse embryos in the Phenogenetics Laboratory at the Institute of General Genetics, Russian Academy of Sciences until 1983. From 1983 to 1988 he studied the effects of narcotic substances on early morphogenesis using bony fish as a model in the Department of Neuropharmacology at the Russian Ministry of Health and received his Ph.D. in embryology and histology in 1988 from the Institute of Developmental Biology, Russian Academy of Sciences.
In 1992, Dr. Kalyuzhny received an invitation to join the Department of Pharmacology, University of Minnesota Medical School. During this time he was investigating the distribution of opioid-binding cell adhesion molecules in the brains of mice chronically treated with morphine. He continued his research career in the Department of Cell Biology & Neuroanatomy (now the Department of Neuroscience) at the University of Minnesota Medical School studying the interaction between opioid receptors and the GABAergic system within the antinociceptive brainstem circuit in rats. This work was funded by an NIH grant awarded to Dr. Kalyuzhny.
Since 1998, Dr. Kalyuzhny has been involved with opioid research, teaching, and editorial work. He also serves as a scientific manager of Immunohistochemistry and the ELISpot laboratory at Bio-Techne, Inc., where he is involved with the development and validation of antibodies for research and clinical applications. Research interests are focused on developing high-sensitivity multi-plex IHC techniques to probe micro-environment of sold tumors.